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Are 4th Generation Synthetic cannabinoids Legal or Not?

Are 4th Generation Synthetic cannabinoids Legal or Not?

I’ll quickly point out I am not a lawyer or legal expert of any kind. The information used to support my argument is based on a personal interpretation of the Federal Law S.3187, evidence was utilized from various first hand source (commentary, opinions by non-experts).

In this post we will be discussing the pro and cons of the legal arguments with regards to whether so-called 4th Generation Synthetic cannabinoids (i.e.: UR-144, 5-fur, 5fakb48, sts-135 ) are in fact legal or not.

UR-144, 5-Fur, 5fakb48, sts-135 are all compounds which research chemists claim are post-ban legal. However, I believe it is dangerous to believe some less then reputable chinese company word for it, considering they don’t even sell that kind of research chemical in there market…

One thing people should seriously consider is that law enforcement agencies continue to try and battle against the ever changing landscape of chemical compounds and chemists which are light years ahead of any legislation. Because they have no legal mechanism for legal arrests, they are progressively getting more and more aggressives in how they deal with manufacturers and distributors who are utilizing loop holes in the law. For example:

Louisiana where UR-144 and 5-Fur were used after the state went ahead before the mentioned federal law passed to ban there own list of compounds. But as the industry began to pump out mass production of these new 4 th generation blends, law enforcement began a brutal crack down across that state.

” Hundreds of individuals were arrested around the state. Operations were shut down. Bank accounts were seized and frozen. Countless man-hours and untold money was spent waging this new war on synthetic drugs. The problem was, most of the people who were arrested, and had their businesses shut down and property seized, weren’t breaking any laws. Chemists and law enforcement seemed to agree – UR-144 and 5FUR-144 were legal.” (source: http://nolacriminallaw.com/)

Law enforcement agencies are bullying people out of the industry by outright illegal arrests! What better way to make someone quit there day job then to throw them in jail, reprimand all there money, post there face all over the media (essentially destroy) someone’s life credibility.  Sure you will get your cash back maybe not your product however, your reputation will be forever destroyed since what is online stays online forever thanks for stupid GOOGLE and company who cache everything for eternity.

Continuing on to the discussion concerning UR-144 and similar compounds, while they are not specifically listed on the Federal Ban, what is cause for concern is this aspect. The government went ahead and defined what a cannabimimetic agent must be:

a) be a CB1 receptor agonist (and this must be backed up with binding studies and function assay research)


b) belong to one of the listed chemical designation classes.

UR-144 and company essentially have an affinity to bind mostly with CB2 receptor however like all synthetics they bind with a very small percentage with CB1 receptor in the brain. UR-144 and company as compounds only fits into category a to certain extend because they mostly bind with CB2 receptor while targeted research chemicals in the past  connected entirely with CB1 receptor. Moreover the government stipulates that a study must be conducted of the particular research chemical to prove its affinity to bind with CB1 receptor and also needs to respect the fact that it needs to belong to the designation classes outlined in the legislature. Because of how new UR-144 and company are its unlikely that there are many labs out there equipped to A) test for that particular compound B) that  they have conducted the aforementioned study of that particular compound.

Although the legislation is therefore not all-encompassing, this legislature and example about busts and scare tactic is sure to have a very chilling effect on the cannabinoid market in the US because it would leave distributors of other cannabinoids very open to prosecution under the Federal Analog Act. With a sympathetic jury federal prosecutors could easily and successfully argue that AB-001 is an analogue of JWH-018 for example, therefore illegal.

The way the bill is worded does raise some interesting questions though. If a novel cannabinoid derivative within one of these chemical classes is synthesized for which no experimental data on CB1 binding is available then is it uncontrolled? How reasonable is it to expect the layman to know whether there is evidence of CB1 agonism for any particular compound given that such information is generally only documented in scientific journals that are often subscription services with high costs? How reasonable is it to expect distributors of such chemicals to know these things? And if new evidence becomes available that demonstrates a novel compound to be a CB1 agonist then what is a reasonable period of time that those in possession of the compound could remain unaware? The extent to which such a broad law will be enforced remains to be seen too. It certainly presents a challenge for both law enforcement and the courts, so I guess we’ll have to wait and see how effective it proves to be should it pass.

UR-144 while it does not bind with CB1 receptor exclusively, but mostly with CB2 receptors then nonethless it binds with CB1 receptor then making that particular compound outlawed… as long as the government comes up with there stupid study demonstrating that… but still I think its a very large cause for concern…

WORD of caution be SAFE, we live in weird times… where now the US government has unlimited ability to spy on you and everything you do… online. (see article interesting read: http://rt.com/usa/news/nsa-whistleblower-binney-drake-978/)

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